|
KMID : 1009020140120020075
|
|
Clinical Psychopharmacology and Neuroscience
2014 Volume.12 No. 2 p.75 ~ p.82
|
|
|
Anti-dementia Activity of Nobiletin, a Citrus Flavonoid: A Review of Animal Studies
|
|
Akira Nakajima
Yasushi Ohizumi
Kiyofumi Yamada
|
|
|
Abstract
|
|
|
|
Alzheimer’s disease (AD), the most common form of dementia among the elderly, is characterized by the progressive decline of cognitive function and has a detrimental impact worldwide. Despite intensive laboratory and clinical research over the last three decades, pharmacological options for the prevention and effective long-term treatment of AD are not currently available. Consequently, successful therapeutic and preventive treatments for AD are needed. When researching materials from natural resources having anti-dementia drug activity, we identified nobiletin, a polymethoxylated flavone from the peel of Citrus depressa. Nobiletin exhibited memory-improving effects in various animal models of dementia and exerted a wide range of beneficial effects against pathological features of AD including amyloid-β (Aβ) pathology, tau hyperphosphorylation, oxidative stress, cholinergic neurodegeneration and dysfunction of synaptic plasticity-related signaling, suggesting this natural compound could become a novel drug for the treatment and prevention of AD.
|
|
|
KEYWORD
|
|
|
Nobiletin, Alzheimer’s disease, Memory, Amyloid β, Hyperphosphorylated tau, Oxidative stress, Cholinergic neurodegeneration
|
|
|
FullTexts / Linksout information
|
|
|
|
|
Listed journal information
|
|
  
|
|